Predictive value of serum d-serine level for hearing impairment in uremic patients

Abstract

Objective

To investigate the predictive value of serum d-serine level for hearing impairment (HI) in uremic patients.

Methods

In this study, 30 uremic patients with HI and 30 with normal hearing were selected. The basic conditions, biochemical indicators, and serum serine levels of the two groups were compared to analyze the influencing factors of HI.

Results

The age and d-serine levels were higher in the HI group, while the l-serine level was lower than uremia in the normal hearing group. Logistic regression analysis showed that d-serine level ≥10 μM and older age increased the risk of HI. The area of the receiver operating characteristic (ROC) curve drawn by the prediction probability of HI was 0.838, indicating that age, d-serine, and l-serine had predictive diagnostic values for HI (p < .001). Among these, the ROC curve area of d-serine in predicting HI in uremic patients was 0.822 (p < .001).

Conclusions

Increased d-serine and age are two risk factors for HI, while l-serine is a protective factor. d-Serine level has a predictive value for HI in uremic patients. Uremic patients are recommended hearing assessment, estimation of d-serine levels, and early intervention.

Keywords:

• d-Serine
• uremic
• hearing impairment
• predictive value

Author contributions

Jiaqing Li performed the experiments, analyzed the data, authored or reviewed drafts of the paper, and approved the final draft. Qing Li conceived and designed the experiments, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft. Ruomei Li performed the experiments, authored or reviewed drafts of the paper, and approved the final draft. Dunlu Yuan and Qing Yang performed the experiments, prepared figures and/or tables, and approved the final draft. Jingjing Huang analyzed the data, prepared figures and/or tables, and approved the final draft. Zhu Zhou analyzed the data, authored or reviewed drafts of the paper, and approved the final draft.

Ethics statement

Experiments were performed under a project license (no. 2022 EA L 45) granted by The Ethics Committee of the First Affiliated Hospital of Kunming Medical University.

Consent form

Not applicable.

Disclosure statement

All authors have no potential conflicts of interest.

Additional information

Funding

This study was supported by grants from the Project of College Education Cooperation Project of Yunnan Province [Grant Number SYSX202034], the Subproject of Fund of CKD Clinical Research Center in Yunnan Province [Grant Number 202102AA100060], the Project of Yunnan Health Training Project of High Level Talents [Grant Number H-2018052], and Hundred of Young and Middle-Aged Academic and Technical Talent in Kunming Medical University [Grant Number 60118260103].