Influencing factors of clinical efficacy of roxadustat among hemodialysis patients

Abstract

Objective

To explore independent influencing factors for clinical efficacy of roxadustat in hemodialysis patients.

Methods

Hemodialysis patients treated with roxadustat were enrolled. The plasma trough concentrations of roxadustat were measured using liquid chromatography–tandem mass spectrometry (LC–MS/MS). A multiple logistic regression model was established to determine the factors that affect clinical efficacy of roxadustat in patients undergoing hemodialysis.

Results

A total of 67 hemodialysis patients were enrolled in the study. The results showed that age, blood trough concentration of roxadustat, and baseline hemoglobin (Hb) level were independent factors of clinical efficacy of roxadustat (OR = 1.06, p = .025 for age; OR = 1.001, p = .037 for plasma concentration; and OR = 0.941, p = .003 for baseline Hb), with an AUC score of 0.859.

Conclusions

Age, blood trough concentration of roxadustat, and baseline Hb level were independent influencing factors of the response to roxadustat in hemodialysis patients.

Keywords:

• Roxadustat
• renal anemia
• blood trough concentration of roxadustat
• clinical efficacy

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The datasets used and analyzed during the study are available from the corresponding author upon reasonable request.

Additional information

Funding

This study was supported by grants from the Science and Technology Bureau of Changzhou (Grant No. CJ20229018), Jiangsu Provincial Medical Youth Talent (Grant No. KY2017142), and Changzhou Youth Talent Fund (Grant No. QN201909).