Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigation

Abstract

Background

The potential impact of elevated intra-abdominal pressure (IAP) on residual renal function (RRF) has not been determined. The objective of this study was to investigate the relationship between IAP and the rate of RRF decline in newly initiated peritoneal dialysis (PD) patients, and to identify the optimal IAP threshold value for delaying the deterioration of RRF.

Methods

A cohort of 62 newly initiated PD patients who completed both 6- and 12-month follow-up evaluations was obtained using the Durand method. A logistic regression model was used to identify variables associated with a rapid decline in RRF. Receiver operating characteristic (ROC) curves were generated to determine the optimal threshold value. Another retrospective cohort analysis was performed to validate the identified critical value.

Results

For each 1 cmH₂O increase in IAP, the risk of a rapid decline in the RRF increased by a factor of 1.679. Subsequent analysis revealed that patients in the high IAP group had more significant decreases in residual renal estimated glomerular filtration rate (eGFR) (Z = −3.694, p < 0.001) and urine volume (Z = −3.121, p < 0.001) than did those in the non-high IAP group. Furthermore, an IAP ≥15.65 cmH₂O was a robust discriminator for the prediction of the rate of RRF decline.

Conclusion

Patients in the high IAP group experienced a more rapid decline in RRF. Additionally, an optimal critical pressure of 15.65 cmH₂O was identified for predicting the rate of RRF decline. IAP, as one of the factors contributing to the rapid decline in RRF in the first year of PD, should be given due attention.

Keywords:

• Peritoneal dialysis
• intra-abdominal pressure
• residual renal function

Acknowledgments

We sincerely appreciate the valuable contributions of Dr Hongliang Rui from Beijing Traditional Chinese Medicine Hospital Affiliated with Capital Medical University during the project design and paper development processes.

Disclosure statement

All the authors declare that they have no conflicts of interest.

Additional information

Funding

This study received support from the following grants: the Science and Technology Program for Medicine and Health Development of Shandong Province(2019WS126), the Science and Technology Development Program of Linyi City (2019190121), the Doctoral Research and Innovation (Start-up) Fund of Linyi People’s Hospital (2016LYBS12), and the Science and Technology Development Program of Weifang Medical University (2023FYM042).