Diagnostic value of multi-parameter ultrasound evaluation in sepsis complicated by acute kidney injury

Abstract

Background

This study aimed to discuss the diagnostic value of multi-parameter ultrasound evaluation in sepsis complicated with acute kidney injury (AKI).

Methods

Patients were divided into an AKI group (n = 50) and a non-injury group (n = 50) based on the presence of AKI. The clinical characteristics were collected, and renal function parameters between the two groups were compared, including 24-h urine volume, serum creatinine, urea, serum cystatin C (CysC), renal parenchymal thickness (RPT), renal artery resistance index (RI), and multi-parameter ultrasound scoring (MPUS). Additionally, logistic regression analysis was conducted to determine the influencing factors of sepsis complicated with AKI. The prediction value was evaluated using a receiver operating characteristic (ROC) curve.

Results

In the AKI group, creatinine, CysC, urea, MPUS score, RPT, and RI values were significantly higher, while the 24-h urine volume was lower than those in the non-injury group (p < 0.01). Moreover, multivariate logistic analysis indicated that high CysC and RI values were independent risk factors, whereas high 24-h urine volume and low MPUS were independent protective factors for sepsis-induced AKI. The ROC curve demonstrated that RI (AUC = 0.906) was more effective than 24-h urine volume (AUC = 0.797), CysC (AUC = 0.730), and MPUS (AUC = 0.794) in identifying sepsis-induced AKI.

Conclusion

High RI values increase the risk of sepsis-induced AKI, whereas low MPUS may reduce it. RI showed high diagnosis values for sepsis complicated with AKI.

Keywords:

• Multi-parameter ultrasound evaluation
• sepsis
• acute kidney injury (AKI)
• risk factors
• application value

Authors’ contributions

Liu Wang designed the study. Xiang Wang collated the data, carried out data analyses and produced the initial draft of the manuscript. Liu Wang and Xiang Wang contributed to drafting the manuscript. All authors have read and approved the final submitted manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

Datasets used in this article are available from the corresponding author on reasonable request.

Additional information

Funding

No funding was received in any form.