The prevalence of functional dyspepsia using Rome IV questionnaire among chronic kidney disease patients

ABSTRACT:

Background: Symptoms of dyspepsia are usually encountered by chronic kidney disease patients. Abdominal discomfort is commonly seen in CKD patients with no other causes of organic affection. Aim: to determine the prevalence of functional dyspepsia in CKD patients, and which subtype is predominant in them. Materials and patients: This observational study included 150 CKD patients. Clinical and laboratory data were recorded for every patient. All the patients were interviewed using the ROME IV questionnaire of functional dyspepsia. Patients fulfilling criteria for functional dyspepsia were exposed to upper GI endoscopy. Results: Overall, 73 (48.7%) of CKD patients were males and 77 (51.3%) were females with mean age of (45.71 ± 9.59) and mean BMI (26.58 ± 5.39). The frequency of functional dyspepsia among CKD patients was determined to be 14.7% (22 out of 150 patients). Among those affected by functional dyspepsia, the most prevalent subtype was found to be Epigastric Pain Syndrome (EPS), accounting for 59% (13 out of 22 cases). The most common predictor of FD in CKD patients was chronic HCV infection, hemodialysis, stage of CKD and eGFR as revealed by Univariate regression analysis. Conclusion: The prevalence of FD amongst CKD patients is 14.7% with EPS the predominant subtype. Male patients, HCV patients, patients with higher CKD stages and highly impaired eGFR (low eGFR) are more probable to have FD.

Keywords:

• CKD
• functional dyspepsia
• EPS
• ROME IV questionnaire

Acknowledgement

We would like to thank all the patients who participated in this work

ZS and OA were concerned with the design of the study; AM, NS and AH were responsible about statistical analysis; BF, SM asses clinical and laboratory parameters; HA, OA and AH analyzed the data and drafted the manuscript. All authors critically revised the manuscript, approved the final version to be published, and agree to be accountable for all aspects of the work.

Ethical approval and consent to participate

Consents were obtained from all individual participants in the study. Institutional Review Board “IRB”, Faculty of Medicine, Minia University, Egypt reviewed and approved the research protocol and consent forms

Consent for publication

Consents were obtained from all individual participants for publication of the work.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability and materials

The article contains all the data produced or analyzed during this research

Additional information

Funding

No Financial support.