SPONTANEOUS APOPTOSIS AND RETINOIC ACID RECEPTOR INCIDENCE IN NEUROBLASTOMAS AND PERIPHERAL NEUROECTODERMAL TUMORS

Parvaneh Farid st Department of Pathology and Experimental Cancer Research, Molecular Pathology Unit, Joint Research Organization of the Hungarian Academy of Sciences and the Semmelweis University of Medicine, Budapest, Hungary

Maria Babosa Department of Pediatrics, Semmelweis University of Medicine, Budapest, Hungary

Peter Hauser Department of Pediatrics, Semmelweis University of Medicine, Budapest, Hungary

Dezso Schuler Department of Pediatrics, Semmelweis University of Medicine, Budapest, Hungary

Bela Szende Department of Pathology and Experimental Cancer Research, Molecular Pathology Unit, Joint Research Organization of the Hungarian Academy of Sciences and the Semmelweis University of Medicine, Budapest, Hungary

Abstract

Twelve cases of neuroblastoma (NB) (7 boys and 5 girls) and 4 cases of primitive peripheral neuroectodermal tumor (PNET) (3 boys and 1 girl) were investigated for the presence of apoptosis and retinoic acid receptor (RAR) by immunhistochemical method. The apoptotic index in NB was zero or 1% in 8 children and relatively low (2-4.8%) in the other 4 cases, while it was higher (4.1-10.5%) in PNET. The RAR index determined by immunoperoxidase reaction in NB was zero or 3% in 5 cases and 9-34% in 7 children. RAR index in PNET was 16-68% in all the 4 cases. Good correlation (r=.47 according to Pearson-Bravis) was found between the number of RAR and spontaneus apoptosis. These results suggest that the RAR index in untreated NB and PNET shows great individual variation since its determination is necessary for the evaluation of the efficacy of retinoic acid treatment.

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SPONTANEOUS APOPTOSIS AND RETINOIC ACID RECEPTOR INCIDENCE IN NEUROBLASTOMAS AND PERIPHERAL NEUROECTODERMAL TUMORS

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SPONTANEOUS APOPTOSIS AND RETINOIC ACID RECEPTOR INCIDENCE IN NEUROBLASTOMAS AND PERIPHERAL NEUROECTODERMAL TUMORS

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