IMMUNOHISTOCHEMICAL ANALYSES OF PHOSPHATASES IN CHILDHOOD B-CELL LYMPHOMA: Lower Expression of PTEN and HePTP and Higher Number of Positive Cells for Nuclear SHP2 in B-Cell Lymphoma Cases Compared to Controls

Marie Fridberg Department of Tumor Biology, Lund University, Malmö University Hospital, Malmö, Sweden

Sofia Kjellström Department of Tumor Biology, Lund University, Malmö University Hospital, Malmö, Sweden

Lola Anagnostaki Department of Pathology, Lund University, Malmö University Hospital, Malmö, Sweden

Ingela Skogvall Department of Pathology, Lund University, Lund, Sweden

Tomas Mustelin Laboratory of Signal Transduction, The Burnham Institute, La Jolla, California, USA

Thomas Wiebe Department of Pediatrics, Lund University, Lund, Sweden

Jenny L. Persson Department of Pathology, Lund University, Malmö University Hospital, Malmö, Sweden

Michael Dictor Department of Pathology, Lund University, Lund, Sweden

Anette Gjörloff Wingren Department of Biomedical Laboratory Science, Health and Society, Malmö University, Malmö, Sweden; Malmö University Hospital, Malmö, Sweden

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Abstract

Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.

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IMMUNOHISTOCHEMICAL ANALYSES OF PHOSPHATASES IN CHILDHOOD B-CELL LYMPHOMA: Lower Expression of PTEN and HePTP and Higher Number of Positive Cells for Nuclear SHP2 in B-Cell Lymphoma Cases Compared to Controls

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IMMUNOHISTOCHEMICAL ANALYSES OF PHOSPHATASES IN CHILDHOOD B-CELL LYMPHOMA: Lower Expression of PTEN and HePTP and Higher Number of Positive Cells for Nuclear SHP2 in B-Cell Lymphoma Cases Compared to Controls

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