Placenta Hominis Protects Osteoporosis in Ovariectomized Rats

H.J. Chae Department of Pharmacology and Institute of Cardiovascular Research, Chonbuk National University Medical School, Jeonju, Chonbuk, South Korea

K.H. Choi Department of Gynecology, School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, South Korea

S.W. Chae Department of Pharmacology and Institute of Cardiovascular Research, Chonbuk National University Medical School, Jeonju, Chonbuk, South Korea

H.M. Kim Department of Pharmacology, Kyung-Hee University College of Oriental Medicine, Seoul, South Korea

T.K. Shin Department of Veterinary Medicine, Jeju National University, Jeju, South Korea

G.Y. Lee Department of Dental Pharmacology and Wonkwang Biomaterial Implant Research Institute, School of Dentistry, Iksan, Chonbuk, South Korea

G.S. Jeong Department of Dental Pharmacology and Wonkwang Biomaterial Implant Research Institute, School of Dentistry, Iksan, Chonbuk, South Korea

H.R. Park Department of Dental Pharmacology and Wonkwang Biomaterial Implant Research Institute, School of Dentistry, Iksan, Chonbuk, South Korea

H.I. Choi Eulji University Hospital, Daejeon, South Korea

S.B. Kim Department of Gynecology, School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, South Korea

S.K. Yoo Department of Gynecology, School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, South Korea

H.R. Kim Department of Dental Pharmacology and Wonkwang Biomaterial Implant Research Institute, School of Dentistry, Iksan, Chonbuk, South Korea

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Abstract

In China, Japan, and Korea, placenta hominis extracts (PHEs) are used clinically for the treatment of osteoporosis. The anti-osteoporotic effect of PHEs was studied. The trabecular bone area and thickness in OVX rats decreased by 50% from those in sham-operated rats; these decreases were completely inhibited by administration of PHEs for 7 weeks. Osteoclast numbers and the osteoblast surface were enhanced in OVX rats, but PHEs had no effect on these phenomena. Serum phosphorus and alkaline phosphatase in OVX rats increased compared to those in sham-operated rats, but the increases were not affected by the administration of PHEs. Thyroxine (T₄) level was stimulated in OVX rats. The extracts inhibited the T₄ level in the OVX rats. These results strongly suggest that PHEs be effective in preventing the development of bone loss induced by OVX in rats.

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Placenta Hominis Protects Osteoporosis in Ovariectomized Rats

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Placenta Hominis Protects Osteoporosis in Ovariectomized Rats

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