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Abstract
Introduction: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion.
Methods: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery.
Results: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers.
Conclusions: SD impairs muscle regeneration in rats, moreover reduces muscular IGF-1 and sleep recovery was able to restore it to basal levels, but it was not enough to normalize the muscle regeneration.
Acknowledgements
The authors thank Associação Fundo de Incentivo à Pesquisa (AFIP). This work was supported by grants from CEPID/SONO-FAPESP (#98/14303-3), FAPESP (#2009/11056-1, #2011/15962-7, #2013/00152-5), CNPq and CAPES.
Declaration of interest
A disclosure statement reporting no conflict has been inserted. Please confirm the statement is accurate.