Role of transforming growth factor-β in airway remodelling in bronchiolitis obliterans

Abstract

Airway remodelling is the main pathological mechanism of bronchiolitis obliterans (BO). Several studies have found that transforming growth factor-β (TGF-β) expression is increased in BO during airway remodelling, where it plays an important role in various biological processes by binding to its receptor complex to activate multiple signalling proteins and pathways. This review examines the role of TGF-β in airway remodelling in BO and its potential as a therapeutic target, highlighting the mechanisms of TGF-β activation and signalling, cellular targets of TGF-β actions, and research progress in TGF-β signalling and TGF-β-mediated processes.

Keywords:

• Transforming growth factor-β
• airway remodelling
• bronchiolitis obliterans
• extracellular matrix
• epithelial-mesenchymal transition

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The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. The authors alone are responsible for the content and writing of the paper.

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Funding

The author(s) reported there is no funding associated with the work featured in this article.