Lymphocytic Meningitis in Patients with Sympathetic Ophthalmia

Abstract

Purpose: This study aimed at reporting lymphocytic meningitis in patients diagnosed with sympathetic ophthalmia (SO).

Methods: In this single-center retrospective observational case series, we reviewed cases diagnosed with SO. We analyzed the patients’ inciting injuries, the characteristics of uveitis and the cerebrospinal fluid (CSF) analyses.

Results: Nine patients were diagnosed with SO and CSF analyses were available in all cases. Four cases had lymphocytic pleocytosis, 3 of which showed marked CSF inflammation with more than 300 lymphocytes/mm³. The inciting event in these 3 patients was a globe perforation injury, whereas 4 patients without meningitis had SO following a surgical intervention.

Conclusions: In this case series of patients with SO, lymphocytic meningitis was a common finding. The prevalence of meningitis in patients with SO and its value for the diagnosis of the disease needs to be further studied.

Keywords:

• Cerebrospinal fluid pleocytosis
• lumbar puncture
• meningitis
• panuveitis
• sympathetic ophthalmia

ACKNOWLEDGMENTS

We would like to thank the whole care team of the department of ophthalmology of Cochin hospital, and especially Aline, for the achievement of this study.

Author contributions: Design and conduct of the study (MMG, SS,MG, APB,DM, and PB); collection,management, and analysis (MMG,MG, SS, DM, and APB); interpretation of the data (MMG, MG, SS, APB); preparation, review, or approval of the study (MMG, MG, SS, PB, DM, and APB).

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.