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Visual Morbidity in Ocular Tuberculosis – Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6

Rupesh Agrawal MD, FCRSa National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore;b Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK;c School of Medicine, National University of Singapore, Singapore, Singapore;d Singapore Eye Research Institute, Singapore, Singapore

https://orcid.org/0000-0002-6662-5850

Dinesh Visva Gunasekeran MBBSa National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore;b Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK;c School of Medicine, National University of Singapore, Singapore, Singapore

Aniruddha Agarwal MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

https://orcid.org/0000-0003-4985-9855

Ilaria Testi MDb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK

Ester Carreño MDf Departamento de Oftalmologiía, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain

Mark Westcott FRCOphthb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK

Sarakshi Mahajan MBBSg Byers Eye Institute, Stanford University, Palo Alto, California, USA

Dhananjay Raje PhDh MDS Bioanalytics, India

Kanika Aggarwal MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Somasheila I Murthy DNBi Tej Kohli Cornea Institute, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India

Soon-Phaik Chee FRCSEda National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore;d Singapore Eye Research Institute, Singapore, Singapore;j Singapore National Eye Centre, Singapore, Singapore;k Department of Ophthalmology & Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore

Peter Mccluskey MDl Department of Clinical Ophthalmology & Eye Health, Central Clinical School, Save Sight Institute, the University of Sydney, Sydney, Australia

Su Ling Ho FRCSGlasga National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore

Stephen Teoh FRCSEda National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore

Luca Cimino MDm Ocular Immunology Unit, Azienda USL IRCCS, Reggio Emilia, Italy

https://orcid.org/0000-0001-7956-9950

Jyotirmay Biswas MSn Department of Ophthalmology, Sankara Nethralaya, Chennai, India

Shishir Narain MDo Department of Ophthalmology, Shroff Eye Centre, New Delhi, India

Manisha Agarwal MSp Department of Ophthalmology, Dr Shroff’s Charity Eye Hospital Daryaganj, New Delhi, India

Padmamalini Mahendradas DNBq Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India

Moncef Khairallah MDr Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Tunisia

Nicholas Jones FRCSOphths Department of Ophthalmology, University of Manchester, Manchester, UK

Ilknur Tugal-Tutkun MDt Istanbul Faculty of Medicine, Department of Ophthalmology, Istanbul University, Turkey

https://orcid.org/0000-0002-4020-453X

Kalpana Babu DNBu Prabha Eye Clinic & Research Centre, Vittala International Institute of Ophthalmology, Bangalore, India

Soumayava Basu MSf Departamento de Oftalmologiía, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain;v Department of Ophthalmology, LV Prasad Eye Institute, Bhubaneswar, India

Richard Lee PhDb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK

Hassan Al-Dhibi MDw Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia

Bahram Bodaghi MDx Department of Ophthalmology, DHU SightRestore, Sorbonne University, Paris, France

Alessandro Invernizzi MDy Department of Biomedical and Clinical Science “L. Sacco”, Eye Clinic, Luigi Sacco Hospital, University of Milan, Italy

https://orcid.org/0000-0003-3400-1987

Debra A. Goldstein MDz Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

Carl P. Herbort MDaa Centre for Ophthalmic Specialised Care & University of Lausanne, Lausanne, Switzerland

Talin Barisani-Asenbauer PhDbb The Centre for Ocular Inflammation and Infection (OCUVAC), Laura Bassi Centre of Expertise Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria

Julio J González-López PhDcc Department of Ophthalmology, Ramón Y Cajal University Hospital, Madrid, Spain

https://orcid.org/0000-0001-7210-7809

Sofia Androudi MDdd Department of Ophthalmology, University of Thessaly, Greece

https://orcid.org/0000-0002-5303-7793

Reema Bansal MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Bruttendu Moharana MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Simona Degli Esposti MDb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK

Anastasia Tasiopoulou MDb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK

Sengal Nadarajah MDb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK

Mamta Agarwal DNBn Department of Ophthalmology, Sankara Nethralaya, Chennai, India

Sharanaya Abraham MDn Department of Ophthalmology, Sankara Nethralaya, Chennai, India

Ruchi Vala MDq Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India

Ramandeep Singh MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Aman Sharma MDee Department of Rheumatology, PGIMER, Chandigarh, India

Kusum Sharma PhDff Department of Microbiology, PGIMER, Chandigarh, India

Manfred Zierhut PhDgg Centre of Ophthalmology, Department of Ophthalmology, University of Tuebingen, Tuebingen, Germany

Onn Min Kon MRCPhh Chest and Allergy Clinic, St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK

Emmett T. Cunningham PhDii The Francis I. Proctor Foundation, UCSF School of Medicine, San Francisco, California, United States

John H. Kempen PhDjj Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States;kk MCM Eye Unit, MyungSung Christian Medical Center and MyungSung Medical School, Addis Ababa, Ethiopia

Quan Dong Nguyen PhDg Byers Eye Institute, Stanford University, Palo Alto, California, USA

Carlos Pavesio FRCSOphthb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK

Vishali Gupta MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaCorrespondence[email protected]

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ABSTRACT

Objective: Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1.

Methods: Multi-center retrospective cohort study. Main outcomes were VI.

Results: A total of 302 patients were included in the study, including 175 patients whose data related to BCVA were available throughout the 2 years of follow up. Mean BCVA grossly improved at 12, 18, and 24 months of follow-up (p < .001). Mean BCVA was worse at 12–18th month follow-up for patients treated with ATT versus patients who were not treated with ATT, but patients treated with ATT had a statistically significant improvement in BCVA at the 24-month endpoint.

Conclusions: OTB is associated with significant visual morbidity, future well-designed prospective studies are warranted to establish the causal association between OTB and visual loss.

KEYWORDS:

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Visual Morbidity in Ocular Tuberculosis – Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6

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