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Original Articles

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population

Ilaria Testia Moorfields Eye Hospital, NHS Foundation Trust, London, UK

, MD,

Rupesh Agrawala Moorfields Eye Hospital, NHS Foundation Trust, London, UK;b Yong Loo Lin School of Medicine, National University of Singapore, Singapore;c National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore;d Singapore Eye Research Institute, Singapore

https://orcid.org/0000-0002-6662-5850

, MD, FRCS

Sarakshi Mahajane Byres Eye Institute, Stanford University, Palo Alto, California, USA

, MBBS,

Aniruddha Agarwalf Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

https://orcid.org/0000-0003-4985-9855

, MS

Dinesh Visva Gunasekeranb Yong Loo Lin School of Medicine, National University of Singapore, Singapore;c National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore

, MBBS,

Dhananjay Rajeg MDS Bioanalytics, Maharashtra, India

, PhD,

Kanika Aggarwalf Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

, MS,

Somasheila I. Murthyh Tej Kohli Cornea Institute, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India

, DNB,

Mark Westcotta Moorfields Eye Hospital, NHS Foundation Trust, London, UK

, FRCOphth,

Soon-Phaik Cheeb Yong Loo Lin School of Medicine, National University of Singapore, Singapore;d Singapore Eye Research Institute, Singapore;i Singapore National Eye Centre, Singapore;j Duke-NUS Medical School, Singapore

, FRCSEd,

Peter Mccluskeyk Department of Clinical Ophthalmology & Eye Health, Central Clinical School, Save Sight Institute, The University of Sydney, Sydney, Australia

, MD,

Su Ling Hoc National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore

, FRCSGlasg,

Stephen Teohc National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore

, FRCSEd,

Luca Ciminol Ocular Immunology Unit, Azienda USL IRCCS, Reggio Emilia, Reggio Emilia, Italy

https://orcid.org/0000-0001-7956-9950

, MD

Jyotirmay Biswasm Department of Ophthalmology, Sankara Nethralaya, Chennai, India

, MS,

Shishir Narainn Department of Ophthalmology, Shroff Eye Centre, New Delhi, India

, MD,

Manisha Agarwalo Department of Ophthalmology, Dr Shroff’s Charity Eye Hospital Daryaganj, New Delhi, India

, MS,

Padmamalini Mahendradasp Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India

, DNB,

Moncef Khairallahq Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia

, MD,

Nicholas Jonesr Department of Ophthalmology, University of Manchester, Manchester, UK

, FRCSOphth,

Ilknur Tugal-Tutkuns Istanbul Faculty of Medicine, Department of Ophthalmology, Istanbul University, Istanbul, Turkey

https://orcid.org/0000-0002-4020-453X

, MD

Kalpana Babut Prabha Eye Clinic & Research Centre, Vittala International Institute of Ophthalmology, Bangalore, India

, DNB,

Soumayava Basuu Department of Ophthalmology, LV Prasad Eye Institute, Bhubaneswar, India

, MS,

Ester Carreñov Servicio de Oftalmología, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain

, MD,

Richard Leea Moorfields Eye Hospital, NHS Foundation Trust, London, UK

, PhD,

Hassan Al-Dhibiw Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia

, MD,

Bahram Bodaghix DHU SightRestore, Department of Ophthalmology, Sorbonne University, Paris, France 

, MD,

Alessandro Invernizziy Eye Clinic, Department of Biomedical and Clinical Science “L. Sacco”, Luigi Sacco Hospital, University of Milan, Italy

https://orcid.org/0000-0003-3400-1987

, MD

Debra A. Goldsteinz Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

, MD,

Carl P. Herbortaa Centre for Ophthalmic Specialised Care, University of Lausanne, Lausanne, Switzerland

, MD,

Talin Barisani-Asenbauerbb The Centre for Ocular Inflammation and Infection (OCUVAC), Laura Bassi Centre of Expertise Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria

, PhD,

Julio J González-Lópezcc Department of Ophthalmology, Ramón Y Cajal University Hospital, Madrid, Spain 

https://orcid.org/0000-0001-7210-7809

, PhD

Sofia Androudidd Department of Ophthalmology, University of Thessaly, Volos, Greece

https://orcid.org/0000-0002-5303-7793

, MD

Reema Bansalf Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

, MS,

Bruttendu Moharanaf Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

, MS,

Simona Degli Espostia Moorfields Eye Hospital, NHS Foundation Trust, London, UK

, MD,

Anastasia Tasiopouloua Moorfields Eye Hospital, NHS Foundation Trust, London, UK

, MD,

Sengal Nadarajaha Moorfields Eye Hospital, NHS Foundation Trust, London, UK

, MD,

Mamta Agarwalm Department of Ophthalmology, Sankara Nethralaya, Chennai, India

, DNB,

Sharanaya Abrahamm Department of Ophthalmology, Sankara Nethralaya, Chennai, India

, MD,

Ruchi Valap Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India

, MD,

Ramandeep Singhf Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

, MS,

Aman Sharmaee Department of Rheumatology, PGIMER, Chandigarh, India

, MD,

Kusum Sharmaff Department of Microbiology, PGIMER, Chandigarh, India

, PhD,

Manfred Zierhutgg Centre of Ophthalmology, Department of Ophthalmology, University of Tuebingen, Tuebingen, Germany

, PhD,

Onn Min Konhh Chest and Allergy Clinic, St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK

, MRCP,

Emmett T. Cunninghamii The Francis I. Proctor Foundation, UCSF School of Medicine, San Francisco, California, USA

, PhD,

John H. Kempenjj Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA;kk MCM Eye Unit, MyungSung Christian Medical Center and MyungSung Medical School, Addis Ababa, Ethiopia

, PhD,

Quan Dong Nguyene Byres Eye Institute, Stanford University, Palo Alto, California, USA

, PhD,

Carlos Pavesioa Moorfields Eye Hospital, NHS Foundation Trust, London, UK

, FRCSOphth &

Vishali Guptaf Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaCorrespondence[email protected] [email protected]

, MS show all

ABSTRACT

Purpose: To examine disease profile of tubercular uveitis (TBU) in Paediatric population.

Methods: Among 945 patients of the retrospective multinational study by the Collaborative Ocular Tuberculosis Study (COTS)-1, 29 Paediatric patients diagnosed with TBU were analyzed.

Results: Mean age of disease presentation was 12.8 (range 4–18 years), with predominance of males (n = 14/20; 70.0%) and Asian ethnicity (n = 25/29; 86.2%). Posterior uveitis (n = 14/28; 50%) was the most frequent uveitis phenotype, with choroidal involvement occurring in 64.7% (n = 11/17). Incidence of optic disc edema and macular edema was higher in children (n = 8/18; 44.4% and n = 5/18; 27.8%, respectively) than in adults (n = 160/942; 16.9% and n = 135/942; 14.3%, respectively). Comparison of optic disc edema between subgroups showed a significant difference (P =.006). All patients received oral corticosteroids, most of them with antitubercular therapy. Treatment failure developed in 4.8% (n = 1/21).

Conclusions: Children have a more severe inflammatory response to the disease, and an intensive anti-inflammatory therapeutic regimen is required to achieve a positive treatment outcome.

KEYWORDS:

Declaration of Interest

All authors do not have any conflicts of interests to declare.

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The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population

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The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population

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