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Letter to the Editor

SARS-CoV-2 Not Detectable in Ocular Specimens of a Patient with a Past Infection

Tina Felfelia Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada;b Dalla Lana School of Public Health, University of Toronto, Toronto, ON, CanadaCorrespondence[email protected]

, MD,

Tony Mazzullic Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;d Department of Microbiology, University Health Network/Mount Sinai Hospital, Toronto, ON, Canada

, MD, FRCPC,

Shawn T. Clarkc Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

, MSc, PhD,

Sherif R. El-Defrawya Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada;e Kensington Vision and Research Centre, Kensington Eye Institute, University of Toronto, Toronto, ON, Canada

, MD, PhD, FRCSC &

Clara C. Chana Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada;e Kensington Vision and Research Centre, Kensington Eye Institute, University of Toronto, Toronto, ON, Canada;f Department of Ophthalmology, Toronto Western Hospital, University Health Network, Toronto, ON, Canada;g Department of Ophthalmology, St. Michael’s Hospital, Unity Health Toronto, Toronto, ON, CanadaCorrespondence[email protected]

, MD, FRCSC

ABSTRACT

Purpose: To present a a case study that aims to investigate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the ocular tissue samples of a patient previously infected with COVID-19 and determine its transmissibility.

Study Design: Case Report

Results: In this case study, SARS-CoV-2 was not detected in the vitreous and uveal tissue samples by RT-PCR for detection of three gene targets in a patient with a past COVID-19 infection 15 days prior to presention with a globe rupture.

Conclusions: Our findings suggest that patients with long-term existence of SARS-CoV-2 at low detectable levels may not have active intraocular viral shedding. This is of particular importance as ophthalmic surgical procedures may potentiate virus spread from patients infected with SARS-CoV-2.

KEYWORDS:

Declaration of interest

The authors have no competing interests and relevant financial disclosures to declare.

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SARS-CoV-2 Not Detectable in Ocular Specimens of a Patient with a Past Infection

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SARS-CoV-2 Not Detectable in Ocular Specimens of a Patient with a Past Infection

ABSTRACT

Declaration of interest

Supplementary material

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