The Multi-Ethnic Pediatric Eye Disease Study: Design and Methods

Rohit Varma Department of Ophthalmology, Doheny Eye Institute, Los Angeles, California, USA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

, MD, MPH,

Jennifer Deneen Department of Ophthalmology, Doheny Eye Institute, Los Angeles, California, USA; Keck School of Medicine, University of Southern California, Los Angeles, California, USA

, MPH,

Susan Cotter Department of Ophthalmology, Doheny Eye Institute, Los Angeles, California, USA; Keck School of Medicine, University of Southern California, Los Angeles, California, USA

, OD, MS,

Sylvia H. Paz Department of Ophthalmology, Doheny Eye Institute, Los Angeles, California, USA; Keck School of Medicine, University of Southern California, Los Angeles, California, USA

, MS,

Stanley P. Azen Department of Ophthalmology, Doheny Eye Institute, Los Angeles, California, USA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

, PhD,

Kristina Tarczy-Hornoch Department of Ophthalmology, Doheny Eye Institute, Los Angeles, California, USA; Keck School of Medicine, University of Southern California, Los Angeles, California, USA

, MD, DPhil,

Peng Zhao Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

, MS &

The Multi-Ethnic Pediatric Eye Disease Study Group See Appendix I

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Abstract

Purpose: To summarize the study design of the Multi-Ethnic Pediatric Eye Disease Study (MEPEDS). Methods: The objectives of the MEPEDS are to: (1) estimate age- and ethnicity-specific prevalence of strabismus, amblyopia, and refractive error; (2) evaluate the association of selected risk factors with these ocular disorders; and (3) evaluate the association of ocular conditions on limitations in health-related functional status in a population-based sample of 12,000 children aged 6–72 months from four ethnic groups—African-American, Asian-American, Hispanics/Latinos and non-Hispanic White. Each eligible child undergoes an eye examination, which includes an interview with his/her parent. The interview includes an assessment of demographic, behavioral, biological, and ocular risk factors and health-related functional status. The examination includes fixation preference testing, visual acuity, stereoacuity, axial length measurement, cycloplegic refraction, keratometry, eye alignment, and anterior and posterior segment examination.

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