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Abstract
The study aims to investigate the body composition and bone mineral density (BMD) characteristics and discuss the relationships among body composition, BMD and sex steroid level in POF. A total of 240 POF patients, 240 normal women, and peri/postmenopausal women (Peri-M/Post-M) (260 patients in each group) were included. Compared to the control group, POF patients? strength of left/right lower limb (SLL/SRL), muscle distributing coefficient of lower limbs (MD) decreased however, waist circumference (WC) and hip circumference (HC) increased. The weight, WC, HC, whole body fat percentage (BF%), average fat distribution (FD), MD of POF patients were lower than those among Peri-M and Post-M and BMD were lower than the Peri-M, yet still higher than Post-M. Moreover, BMD were significantly positively correlated with BF%, FD, SLL, MD and estradiol (E2). The factors associated with L2–L4 BMD were E2, SRL, FD and age. For the FN BMD, the factors were FD, E2 and SLL. Therefore, we conclude that maintenance of appropriate weight, physical exercise and hormone replacement treatment (HRT) may have positive effects on increasing BMD, improving muscle mass and muscle strength, preventing osteoporosis.
摘要
本研究旨在探讨体成分和骨密度（BMD）特征, 并探讨POF患者体成分、骨密度和性类固醇水平之间的关系。共纳入240名POF患者、240名正常女性和围绝经期/绝经后女性（Peri-M/Post-M）（每组260名患者）。与对照组相比, POF患者左/右下肢力量（SLL/SRL）、下肢肌肉分布系数（MD）下降, 腰围（WC）和臀围（HC）增加。POF患者的体重、WC、HC、全身脂肪百分比（BF％）、平均脂肪分布（FD）、MD均低于Peri-M和Post-M；BMD均低于Peri-M, 即便如此, 仍高于Post-M。此外, BMD与BF％、FD、SLL、MD和雌二醇（E2）显著正相关。与L2-L4 BMD相关的因素是E2、SRL、FD和年龄。对于FN BMD, 相关因素是FD、E2和SLL。因此, 我们得出结论, 维持适当的体重、体育锻炼和激素替代治疗（HRT）可能对增加BMD、改善肌肉质量和肌肉力量、预防骨质疏松症有积极作用。
Disclosure statement
No potential conflict of interest was reported by the authors.