Serum oxytocin profiles in patients with repeated implantation failure during IVF cycles

Abstract

Objective: The objective of this study is to investigate the association between oxytocin (OT) levels and repeated implantation failure (RIF) during in vitro fertilization-embryo transfer (IVF-ET) cycles.

Methods: Blood samples were collected from 108 women undergoing IVF-ET treatment at the following time points: gonadotrophin (Gn) administration day (Gn Day 0), hCG administration day (hCG Day 0), ET administration day (ET Day 0), and 5 d after ET (ET Day 5). Serum OT and steroid profiles were measured and compared among three groups: Group A included 38 women with a history of RIF, Group B included 41 women who became pregnant following the first fresh ET, and Group C included 29 women who did not become pregnant following the first fresh ET.

Results: The OT levels of the three groups at different time points were not significantly different. Serum OT levels were significantly higher on hCG Day 0, ET Day 0, and ET Day 5 than on Gn Day 0, and they were significantly correlated with the estradiol concentration on ET Day 0.

Conclusions: RIF patients do not have elevated serum OT levels during IVF-ET cycles.

摘要

目的：本研究的目的是评估IVF-ET周期中反复种植失败（RIF）和缩宫素(OT)水平之间的关系。

方法：收集了108名IVF-ET 患者四个时间点的血样：启动日 (Gn Day 0), 扳机日 (hCG Day 0), 胚胎移植日 (ET Day 0), 和胚胎移植后5天。测量三组的血清缩宫素和类固醇并比较： A组包括38名有RIF病史的女性, B组包括41名初次种植新鲜胚胎并怀孕的女性, C组包括29名初次种植新鲜胚胎但未怀孕的女性。

结果：三组不同时间点的OT水平无统计学差异。扳机日、胚胎移植日、移植后5天的OT值明显高于启动日, 而且与移植日的雌二醇水平有相关性。

结论：RIF患者在IVF-ET周期中OT水平没有明显升高。

Keywords:

• Oxytocin
• gonadal hormones
• embryo transfer
• infertility
• uterine contraction

Disclosure statement

The authors report no conflicts of interest.

Additional information

Funding

This study has been supported by the Natural Science Foundation of Guangdong Province [2016A030310142] and the Fundamental Research Funds for the Central Universities [16ykpy44].