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Abstract
Current studies have focused more on the relationships among estrogen, androgen, and metabolic syndrome (MetS). The main aim of the study was to investigate whether the variation of FSH is associated with metabolic factors in postmenopausal women. A total of 561 postmenopausal women aged 39–69 years were selected. FSH, estradiol, fasting blood glucose, and lipid profiles were analyzed. Compared with women in the highest FSH quartile, women in the lowest quartile had higher body mass index (BMI), fast blood glucose (FBG), triglyceride (TG), blood pressure, and serum estradiol (E2) but lower high-density lipoprotein (HDL) (all p < .05). Compared with women in the groups of normal levels of MetS biomarkers, women in the abnormal groups had lower FSH (all p < .01). Increased quartiles of FSH were associated with significantly decreased rates of abnormal levels of metabolic factors (all p < .05). High FSH levels had protective effects regarding SBP, DBP, and FBG, with odds ratios (ORs) of 0.84 (95% CI 0.76–0.92, p < .001), 0.85 (95% CI 0.78–0.94, p < .01), 0.90 (95% CI 0.83–0.98, p < .01), respectively. Low FSH appears to be a risk factor of all domains of MetS in postmenopausal women, which merits further study.
摘要
当前已经有很多研究在关注雌激素, 雄激素和代谢综合征之间的关系。本研究的目的主要是探讨绝经后女性FSH的波动是否与代谢因素相关。共选择了年龄在39-69岁之间的绝经后女性561名。我们分析了这些患者的FSH, 雌激素, 快速血糖和血脂。与有着较高FSH水平的绝经期女性相比, 体内FSH较低的绝经后女性的BMI较大, 快速血糖、甘油三脂、血压及血清雌二醇较高, 而高密度脂蛋白较低（p<0.05）。与代谢生物指标正常组绝经后女性相比, 代谢指标异常组患者的FSH值偏低（p<0.01）。FSH的增加与代谢因子异常水平的显著降低有关（p<0.05）。高水平的FSH对于收缩压, 舒张压及空腹血糖具有保护效应, 这三个因素的OR值分别为0.84 (95% CI 0.76–0.92, p<0.001), 0.85 (95% CI 0.78–0.94, p<0.01), 0.90 (95% CI 0.83–0.98, p<0.01)。低水平的FSH值似乎是绝经后女性代谢相关的危险因素, 这值得进行深入的研究。
Disclosure statement
No potential conflict of interest was reported by the authors.