The effect of performing hysteroscopy prior to the first in vitro fertilization (IVF) cycle on live birth rate

Abstract

In this retrospective cohort study, a total of 707 couples underwent in vitro fertilization (IVF) at Hacettepe University Hospital between 01 January 2010 and 01 November 2014 with their chronologically first cycle were evaluated. Patients who have diagnostic hysteroscopy prior to first IVF cycle served as a study group (n = 42) and patients without diagnostic hysteroscopy served as control group (n = 282). In study group in all patients, diagnostic hysteroscopy was performed at the follicular phase of previous menstrual cycle, namely immediately before ovarian stimulation (OS) cycle. Demographic features, clinical characteristics and treatment outcomes were compared between the groups. The logistic regression analysis was performed in order to assess independent predictors of live birth rates (LBRs). There was no statistically significant difference between the groups for demographic features and OS cycle characteristics. Implantation rate (22.2% vs. 21.5%, p=.840), clinical pregnancy rate (33.3% vs. 28.7%, p=.541), and LBRs (23.8% vs. 18.5%, p=.420) were comparable. In logistic regression analysis, performing hysteroscopy prior to first IVF cycles per se without correcting anatomic abnormalities was not an independent predictor of LBRs (OR: 0.72, 95% CI: 0.310–1.68, p=.45). In conclusion, performing diagnostic hysteroscopy prior to first IVF treatment cycle without correcting any anatomic abnormalities did not improve LBRs.

摘要

在这项回顾性队列研究中, 在Hacetepe大学医院2010年1月1日至2014年11月1日期间共有707对夫妇在接受了体外受精（IVF）, 并按时间顺序第一个周期进行了评估。在第一个IVF周期之前进行诊断性宫腔镜检查的患者为研究组(n=42), 未进行诊断性宫腔镜检查的患者为对照组(n=282)。研究组在前一次月经周期的卵泡期, 即卵巢刺激周期之前立即进行诊断性宫腔镜检查。比较两组的人口学特征、临床特征和治疗结果。Logistic回归分析用于评估活产率的独立预测因素。在人口统计学特征和卵巢刺激周期特征上, 两组间无统计学差异(P>0.05)。种植率(22.2%vs.21.5%, p=0.840)、临床妊娠率(33.3%vs.28.7%, p=0.541)和活产率(23.8%vs.18.5%, p=0.420) 方面相当。在Logistic回归分析中, 在第一个体外受精周期之前进行宫腔镜检查而不纠正解剖异常本身并不是LBR的独立预测因素(OR：0.72, 95%CI：0.310-1.68, p=0.45)。总之, 在没有纠正任何解剖异常的情况下, 在第一个IVF治疗周期之前进行诊断性宫腔镜检查并不能改善其活产率。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• In vitro fertilization
• hysteroscopy
• live birth rate

Acknowledgements

We would like to thank our medical staff who have worked so diligently to provide better services to the patients.

Disclosure statement

The authors state no conflict of interest in this study.