State of the art and emerging drug therapies for female infertility

Abstract

At present, infertility is a key-issue. When applicable, in vitro fertilization (IVF) has become the standard approach to treat this condition but a thorough investigation and, whenever possible, the individual diagnosis of the underlying causes of infertility are required. For many female causes, indeed, efficient medical therapies are available to achieve a fast solution of the problem. This review is based on the relevant literature indexed in PubMed and SCOPUS and is focused on the most recent clinical literature on the treatment of women (and couples) affected from infertility. The reduction in IVF treatment burden and risks are now considered pivotal to set ‘patient-friendly’ therapies and represent crucial issues for both patients and physicians. To this end, the researchers are now focusing their attention on old drugs with new indications and new compounds with more appropriate functions, to improve the compliance of the women and reduce the burden of infertility, a condition that is becoming an important issue in the modern world, also for the Public Health System.

摘要

目前, 不孕症时一个重要问题。体外受精（IVF）已成为治疗不孕症的标准方法, 但需要进行全面的调查, 并在可能的情况下对不孕的潜在原因进行个体化的诊断。事实上, 对于许多女性来说, 有效的医学治疗可以快速解决这个问题。这篇综述基于PubMed和SCOPUS相关文献, 主要关注最近关于治疗和不孕女性（和夫妇）的临床文献。减少体外受精治疗负担和风险是建立“爱伤”治疗的关键, 对患者和医师来说都是至关重要的。为此, 研究人员正在主要关注于老药新适应证和新药新的功能, 提高女性的用药依从性, 减少不孕症的负担。这一状况成为当代世界的一个重要问题, 对公共卫生系统也是如此。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Antagonist protocol
• controlled ovarian hyperstimulation
• gonadotrophin
• infertility
• IVF
• DuoStim
• progesterone

Disclosure statement

The authors do not have any conflict of interest to claim.