The effect of premature ovarian insufficiency on nasal mucociliary clearance time

Abstract

Premature ovarian insufficiency (POI) is a global health concern for women and affects several systems, such as cardiovascular system, autoimmune disease, and psychological status. The aim of this study was to investigate the effect of POI on nasal mucociliary clearance time via saccharin test by comparing postmenopausal women and healthy controls. Thirty-five (35) patients with POI, 35 healthy postmenopausal women and 35 healthy controls were recruited in this study. All study participants underwent measurements of nasal mucociliary clearance time via saccharine test. When women with POI and postmenopausal women compared with the controls, nasal mucociliary clearance time was longer in both women with POI and postmenopausal women. When women with POI were compared with postmenopausal women, the nasal mucociliary clearance time was not difference between two groups. There was a significant prolonged nasal mucociliary clearance time in the women with POI and postmenopausal women. Lower serum estradiol levels in women with POI as well as postmenopausal women had an adverse effect of nasal mucociliary clearance time.

摘要

早发性卵巢功能不全(premature ovarian insufficiency, POI)是全球女性关注的一个健康问题之一, 产生多系统的影响, 如心血管系统、自身免疫性疾病和心理状态。本研究的目的是通过糖精试验探讨POI与绝经后女性和健康对照组相比对鼻黏膜纤毛清除时间的影响。本研究共纳入35例原发性卵巢功能不全患者, 35例绝经后女性和35例健康对照组。所有的纳入者都参加了糖精试验测量鼻黏膜纤毛清除时间。与对照组相比, POI组和绝经后女性组鼻黏膜纤毛清除时间更长。与绝经后女性组相比, POI组鼻纤毛清除时间无明显差异。POI组与绝经后女性组鼻黏膜纤毛清除时间明显延长。POI患者和绝经后女性血清雌二醇水平较低, 对鼻黏膜纤毛清除时间有不利的影响。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Menopause
• nasal mucociliary dysfunction
• nasal mucociliary clearance time
• premature ovarian insufficiency
• saccharin test

Disclosure statement

The authors report no conflict of interest.