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Abstract
Polycystic ovary syndrome (PCOS) is commonly associated with metabolic disorders, which are exacerbated by obesity. Recent studies have revealed that oxytocin contributes to metabolic, appetite, and body weight regulation. In the present study, we evaluated the effects of chronic administration of oxytocin on body weight, food intake, and fat mass in a dihydrotestosterone-induced rat model of PCOS. Body weight, body weight change, and relative cumulative food intake were significantly lower in the oxytocin-treated PCOS rats than in the vehicle-treated control PCOS rats. Similarly, visceral adipocyte size was significantly smaller in the oxytocin-treated PCOS rats than in the vehicle-treated control PCOS rats. On the other hand, the numbers of cystic follicles in the ovary did not differ between the two groups. The chronic administration of oxytocin did not affect the rats’ serum aspartate aminotransferase, alanine aminotransferase, or lactate dehydrogenase levels, indicating that it does not have adverse effects on hepatic function. These findings suggest that oxytocin could be a candidate drug for preventing the onset of obesity-related metabolic disorders in PCOS patients.
摘要
多囊卵巢综合征（PCOS）通常与代谢紊乱相关, 肥胖会加重代谢紊乱。最近的研究表明, 催产素有助于代谢、食欲和体重调节。在本研究中, 我们用双氢睾酮诱导多囊卵巢综合征大鼠模型, 评估了长期服用催产素对体重、食物摄入量和脂肪含量的影响。经催产素处理的多囊卵巢综合征的大鼠体重、体重改变和相对积累食物摄取量显著低于空白处理的多囊卵巢综合征大鼠。同样地, 经催产素处理的多囊卵巢综合征大鼠的内脏脂肪细胞大小明显小于空白处理的多囊卵巢综合征大鼠。另一方面, 卵巢中卵泡数量在两组间没有差异。长期予以催产素处理对大鼠的血清天门冬氨酸转氨酶、丙氨酸转氨酶、乳酸脱氢酶水平无差异, 说明对肝功能无不良影响。这些发现表明, 催产素可能是一种候选药物, 用于预防PCOS患者出现与肥胖相关的代谢紊乱。
The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
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Disclosure statement
The authors declare that they have no conflicts of interest.