Adiponectin (ADIPOQ) gene variants and haplotypes in Saudi Arabian women with polycystic ovary syndrome (PCOS): a case–control study

Abstract

The aim of this study is to assess the association of nine SNPs on ADIPOQ on the PCOS risk among Saudi Arabian Women. A case–control study, including 162 cases and 162 controls in Saudi Arabia, was enrolled. Genotyping was carried out by the allelic discrimination method. Estimated haplotype frequencies were assessed using the maximum likelihood method. Results showed that ADIPOQ SNPs were not associated with PCOS for allelic and genotypic frequencies (p > .05). In haplotype estimation analysis, a significant positive association was detected between 21211 haplotype (rs2241766/rs1501299/rs2241767/rs3774261/rs17366743) in additive model with increased risk of PCOS (p = .009, OR = 2.16 [1.22–3.82] CI 95%). None of the nine SNPs illustrated significant association with the quantitative traits after multiple test corrections. These results support a significant association of 21211 haplotype (rs2241766/rs1501299/rs2241767/rs3774261/rs17366743) of ADIPOQ gene in Saudi women with polycystic ovary syndrome.

摘要

本研究的目的是评估九个脂联素单核苷酸多态性与沙特阿拉伯妇女多囊卵巢综合征风险的相关性。在沙特阿拉伯进行了一项病例对照研究, 包括162例病例和162例对照。基因分型采用等位基因判别法。估计的单倍型频率使用最大似然法进行评估。结果表明, 在等位基因频率和基因型频率上, 脂联素单核苷酸多态性与多囊卵巢综合征无关（p>0.05）。在单倍型估计分析中, 在加性模型中, 21211个单倍型（rs2241766/rs1501299/rs2241767/rs3774261/rs17366743）与多囊卵巢综合征风险增加之间存在显著的正相关（p＝0.009, OR＝2.16 [1.22–3.82] CI 95%）。九个单核苷酸多态性经多次检验校正均未显示与数量性状有显著相关性。这些结果支持患多囊卵巢综合征的沙特妇女与脂联素基因21211个单倍型（rs2241766/rs1501299/rs2241767/rs3774261/rs17366743）的显著相关性。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• GWAS
• SNPs
• T2D
• PCOS

Acknowledgments

The authors gratefully acknowledge all of the patients and volunteers for their participation. The authors also thank the nurses and physicians for their contribution to the collection of all samples in King Salman Military Hospital of Tabuk, Saudi Arabia.

Disclosure statement

The authors declare that they have no competing interests.

Additional information

Funding

The authors would like to extend their sincere appreciation to the Deanship of Scientific Research at the University of Tabuk for its funding of this research through the Research Group Project no. S1436-0288.