Serum HSP70 level in patients with endometrial cancer with and without diabetes

Abstract

Diabetes mellitus (DM) is associated with an increased risk of endometrial carcinoma (EC). Heat shock proteins have a role in the modulation of both diseases. The aim of this study was to investigate extracellular HSP70 (eHSP70) level alternations in patients with two different types of EC (endometrioid and non-endometrioid) with and without type 2 diabetes. In a case–control study, 88 participants were enrolled in four groups including: 18 EC patients with DM, 19 EC patients without DM, 29 patients with DM, and 22 healthy individuals. Blood samples were taken before surgery in cancer patients. Estradiol, eHSP70, sex hormone-binding globulin (SHBG), FBS, and HbA1c were assessed. Serum HSP70 level was higher in patients with diabetes (52.24 ± 14.2 ng/ml) compared to healthy controls (39.04 ± 6.96) (p < .05). It was lower in EC (26.05 ± 12.28) compared to healthy controls (39.04 ± 6.96) (p < .05). eHSP70 was also lower in endometrioid-type carcinoma (22.57 ± 11) compared to non-endometrioid type (31.55 ± 12.38) (p < .05). Further analysis showed increased levels of eHSP70 in patients having both endometrioid-type carcinoma and diabetes (27.23 ± 11.41) compared to the same patients without DM (17.08 ± 7.78) (p < .05). Presence of diabetes in patients with endometrioid type carcinoma resulted in an increase in eHSP70 approaching the level of eHSP70 in patients with non-endometrioid histology.

摘要

糖尿病（DM）与子宫内膜癌（EC）的风险增加相关。热休克蛋白在调节这两种疾病中都有作用。本研究的目的是探讨两种不同类型的EC（子宫内膜样和非子宫内膜样）患者有2型糖尿病和无2型糖尿病的细胞外HSP70（eHSP70）水平变化。在这项病例对照研究中, 纳入88名参与者, 分为四组：18名患有DM的EC患者, 19名无DM的EC患者, 29名DM患者, 和22名健康个体。对肿瘤患者进行术前采血。评估雌二醇、eHSP70、性激素结合球蛋白（SHBG）、FBS和糖化血红蛋白水平。糖尿病患者血清HSP70水平（52.24±14.2ng/ml）高于健康对照组（39.04±6.96ng/ml）（p＜.05）。EC组（26.05±12.28ng/ml）低于健康对照组（39.04±6.96ng/ml）（p＜.05）。子宫内膜样 (22.57±11ng/ml)与非子宫内膜样癌(31.55±12.38ng/ml) 相比, eHSP70也较低(p<.05)。进一步分析发现, 子宫内膜样癌合并糖尿病患者的eHSP70水平 (27.23±11.41ng/ml)高于未合并糖尿病的患者(17.08±7.78ng/ml) (p<.05)。糖尿病患者的子宫内膜样癌导致eHSP70的增加接近于非子宫内膜癌样患者的eHSP70的水平。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Heat shock protein70
• endometrioid-type carcinoma
• non-endometrioid-type carcinoma
• Type 2 diabetes

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Elite Researcher Grant Committee under Grunt number 958320 from the National Institutes for Medical Research Development (NIMAD), Tehran, Iran.