Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms

Abstract

Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin^®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin^® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin^®, an SSRI-‘like’ therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin^® may also be a suitable option for the management of menopausal symptoms in women with breast cancer.

摘要

非激素替代疗法的研究对于绝经期激素治疗禁忌的妇女或不希望服用激素的妇女是必要的。这篇综述着重介绍了一种非激素的选择, 即纯化和特异性细胞质花粉提取物或PureCyTonin^®。此提取物已经在多项临床前和临床研究中被评估, 并证明了其作为绝经期安全且无雌激素替代品的价值。这篇综述介绍了PureCyTonin^® 在治疗健康女性绝经期症状(如潮热)以及经前综合征方面的有益作用。我们讨论了PureCyTonin^® 的作用机制, 这是一种类似SSRI的疗法。临床前研究表明, PureCyTonin^® 缺乏雌激素作用可能也是治疗乳腺癌女性绝经期症状的合适选择。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Purified and specific cytoplasmic pollen extract
• PureCyTonin^®
• menopause
• non-hormonal alternative
• hot flushes
• premenstrual syndrome
• Serelys^®

Disclosure statement

Andrea Genazzani: Consultant and occasional presentations for Abbot, Alfa Sigma, Bionorica, Endoceutics, Exeltis, Grunenthal, Mithra, MSD, Se-Cure, Pharma, Serelys Pharma, IBSA, Theramex.

Nick Panay: Speaker’s bureau: Abbott, Bayer, Besins, Meda, MSD, Mylan, Novo Nordisk, SeCur, Shionogi, Theramex. Advisory Committee: Abbott, Bayer, Besins, Meda, Mithra, MSD, Mylan, Novo Nordisk, Kora, SeCur, Shionogi. RESEARCH GRANTS: Abbott, Asarina, Mithra, Mylan, NeRRe, Pharm Olam, Yes Company.

Tommaso Simoncini, Herman Depypere, Christian Egarter, Nicoletta Biglia, Tomas Fait, Martin Birkhaeuser, Sven O. Skouby, Mark Brincat, Cuauhtémoc Celis-Gonzales: No potential conflicts of interest were reported by the authors.

Steven Goldstein: Gyn Advisory Boards for AbbVie, Amag, Amgen, Astellas, Therapeutics MD.

Xiangyan Ruan: Experimental research on Purified and Specific Cytoplasmic Pollen Extract was financially supported by Serelys Pharma.

Santiago Palacios: Symposium speaker or advisory board member for Shionogi, Pfizer, Lacer, Theramex, Procare, Serelys Pharma, and Amgen. Received research grants and/or consulting fees from Pfizer, Serelys Pharma, Amgen, MSD, Seid, lacer, Leon Farma, Gynea, and Sandoz.