Abstract
Aim
To assess serum chemerin levels and investigate the association of chemerin with the hyperandrogenic and normoandrogenic phenotypes of Polycystic Ovary Syndrome (PCOS) and with the metabolic status of the analyzed population.
Material and methods
A cross-sectional study was conducted on 106 women with PCOS and 60 healthy controls from Argentina. Patients were classified as showing a hyperandrogenic or normoandrogenic phenotype. Participants underwent anthropometric and clinical evaluation and markers of cardiovascular risk, insulin resistance, metabolic syndrome (MS), and serum chemerin levels were assessed.
Results
PCOS patients showed increased levels of chemerin. In adjusted models for age and body mass index (BMI), chemerin was associated with markers of metabolic status. The analysis of chemerin levels considering the cutoff values of BMI, homeostatic model of insulin sensitivity (HOMA-IR) and TG/HDL marker showed that PCOS patients always presented higher levels of chemerin than controls. PCOS group showed increased chemerin levels independently of the presence of MS.
Conclusion
PCOS patients always showed increased levels of chemerin independently of their phenotype and presence of overweight, as well as higher levels of chemerin than controls when considering the cutoff values of HOMA-IR and TG/HDL. Therefore, argentine women with PCOS display increased chemerin levels independently of their metabolic or androgenic status.
摘要
目的:研究高雄激素血症的多囊卵巢综合征患者和雄激素水平正常的患者的血清趋化素水平, 研究血清趋化素水平与被分析人群代谢状态的关系。资料和方法:对106名PCOS妇女和60名健康对照者进行了横断面研究。患者被分为高雄激素组和正常雄激素组。受试者接受了人体测量和临床评估, 并评估了心血管风险、胰岛素抵抗、代谢综合征和血清趋化素水平的指标。结果:PCOS患者的血清趋化素水平增加。通过对年龄和体重指数(BMI)校正模型分析显示, 趋化素水平与代谢状态的标记物有关。对趋化素水平的分析考虑了体重指数、胰岛素敏感性稳态模型(HOMA-IR)和甘油三酯/高密度脂蛋白标记物的临界值, 结果显示PCOS患者的趋化素水平始终高于对照组。动脉粥样硬化的独立存在与PCOS组趋化素水平的增加有关。结论:当考虑HOMA-IR和甘油三酯/高密度脂蛋白的临界值时, PCOS病患者总是表现出与他们的表型和是否超重无关的趋化素水平的增加, 同时, PCOS组的趋化素水平较对照组更高。因此, 阿根廷的患有PCOS病的女性无论其代谢或雄激素状态如何, 都表现出趋化素水平的增加。
Acknowledgements
The authors thank Cecilia Gorla for her technical support.
Disclosure statement
The authors report no conflicts of interest.