Gestational diabetes mellitus is associated with blood inflammatory indicators in a Chinese pregnant women population

Abstract

Objective

This study aimed to investigate relationships between blood inflammatory and metabolic biomarkers in pregnant Chinese women with gestational diabetes mellitus (GDM) in Southwest China and to compare the contributions of blood inflammatory indicators to GDM identification.

Subjects and methods

In total, 1,347 pregnant women were divided by gestational week into early-, middle- and late-pregnancy groups. Fasting samples were collected for complete blood count (CBC) and biochemical indicator measurements. Receiver operating characteristic (ROC) curves were used to predict GDM. Multivariate logistic regression was used to examine the associations between blood inflammatory indicators and GDM prevalence in pregnant women.

Results

Significant differences were found in blood inflammatory indicators and metabolic markers in different pregnancy trimesters. For the pregnant women with GDM, FPG, 1 h-PG, 2 h-PG levels, NLR and PLR, WBC and neutrophil counts were statistically differences when compared with non-GDM groups. ROC curve analysis indicated that the NLR, PLR, WBC and neutrophil counts have predictive value for GDM from 24–28 gestational weeks. The FPG levels in 24th–28th weeks of pregnant women were positively correlated with the NLR, PLR, 1 h-PG, 2 h-PG levels and negatively correlated with lymphocyte count. Following adjustment for the age, PLR, and FPG level, multivariate logistic regression showed that the NLR was an independent factor predicting GDM in the 24th–28th weeks of pregnancy.

Conclusion

The blood inflammatory indicators NLR, PLR, and WBC and neutrophil counts were higher in GDM women than in healthy pregnant women, suggesting that blood inflammatory indicators are associated with GDM.

妊娠期糖尿病与中国孕妇的血液炎症指标相关 摘要

目的: 本研究旨在探讨中国西南地区妊娠期糖尿病(GDM)孕妇血液炎症指标与代谢指标之间的关系, 比较血液炎症指标在GDM诊断中的作用。

研究对象和方法:将1347名孕妇按孕周分为早孕组、中孕组和晚孕组。采集空腹血样进行全血细胞计数(CBC)和生化指标测定。采用ROC曲线来预测GDM。采用多因素logistic回归分析来检验血液炎症指标和妊娠期糖尿病患病率的相关性。

结果:不同孕周的血液炎症指标和代谢指标之间存在显著差异。对于GDM孕妇, FPG、1h-PG、2h-PG水平、NLR和PLR、WBC和中性粒细胞计数与非GDM组相比有统计学差异。ROC曲线分析表明, NLR、PLR、WBC和中性粒细胞计数对24-28孕周的GDM有预测价值。孕妇第24-28周的FPG水平与NLR、PLR、1h-PG、2h-PG水平呈正相关, 与淋巴细胞计数呈负相关。在对年龄、PLR和FPG水平进行调整后, 多因素logistic回归分析显示NLR是预测妊娠24-28周GDM的独立因素。

结论:GDM孕妇血液炎症指标NLR、PLR、WBC和嗜中性粒细胞计数均高于健康孕妇, 提示血液炎症指标与GDM有关。

Keywords:

• Inflammation
• blood
• pregnancy
• gestational diabetes mellitus

Disclosure statement

The authors declare that they have participated sufficiently in the work and take responsibility for the appropriate portions of the content. The authors declare no conflicts of interest in this work.

Additional information

Funding

The clinical case screening and data collection were supported by the Sichuan Provincial Science and Technology department Research Foundation of China [2020YFS0494] and Chengdu Science and Technology bureau: technology innovation research and development project [2020-YF05-00200-SN].