Effect of the increase rate of blood lipid concentration during pregnancy on the adverse pregnancy outcomes: a cohort study of 1051 singleton pregnancy

Abstract

Objective

To investigate the effects of blood lipid concentration and blood lipid growth rate in the first and third trimesters of pregnancy on adverse pregnancy outcomes.

Methods

The study subjects were 1051 singleton pregnant women who established archives in Chengdu Maternity and Child Specialty Hospital. The pregnancy information was continuously recorded until the pregnant woman gave birth, and lipid biochemical indicators were performed every three months.

Results

The average age of the pregnant women recruited was 27.82 ± 3.07 years. Compared with the first trimester, the concentration of triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in the third trimester were increased significantly (all p < .05). The growth rate of triglyceride was closely related to the occurrence of gestational diabetes mellitus and large for gestational, and the growth rate of total cholesterol and low-density lipoprotein cholesterol was closely related to gestational diabetes mellitus and cholestasis of pregnancy. For every unit increase in triglyceride growth rate, the risk of gestational diabetes mellitus and large for gestational age increases by 1.237 times and 1.317 times, respectively.

Conclusion

Among non-high-risk pregnant women, blood lipid concentration is generally high among pregnant women with complications during pregnancy. It is necessary to combine a single blood lipid test concentration during pregnancy with the blood lipid growth rate to assess the condition of pregnant women and provide better guidance during pregnancy.

摘要

目的

探讨妊娠早、晚期血脂浓度和血脂增长率对不良妊娠结局的影响。

方法

研究对象为在成都市妇幼专科医院建立档案的1051名单胎孕妇。持续记录孕期信息, 直至孕妇分娩, 每三个月进行一次血脂生化指标检查。

结果

招募的孕妇平均年龄为27.82±3.07岁。与孕早期相比, 孕晚期甘油三酯、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的浓度显著升高（均p < 0.05）。甘油三酯的增长速度与妊娠期糖尿病和大于胎龄儿的发生密切相关, 总胆固醇和低密度脂蛋白胆固醇的增长速度与妊娠期糖尿病和妊娠期胆汁淤积密切相关。甘油三酯增长率每增加一个单位, 患妊娠期糖尿病和大于胎龄儿的风险分别增加1.237倍和1.317倍。

结论

非高危孕妇中, 孕期有并发症的孕妇血脂浓度普遍偏高。有必要结合孕期单次血脂检测浓度和血脂增长率来评估孕妇的状况, 更好地指导孕期。

Keywords:

• Pregnancy
• blood lipid concentration
• adverse pregnancy outcomes

关键词:

• 妊娠
• 血脂浓度
• 不良妊娠结局

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was funded by National key research and development projects of China (2017YFC0907304)