Antioxidant supplements relieve insulin resistance but do not improve lipid metabolism in women with polycystic ovary syndrome: a meta-analysis of randomized clinical trials

Abstract

Objective: The effect of antioxidant supplements on glucose metabolism and lipid profiles in polycystic ovary syndrome (PCOS) remains controversial. This systematic review and meta-analysis aimed to evaluate whether antioxidant supplements improve glucose metabolism and lipid profiles in women with PCOS to provide optimal nutritional supplement advice in clinical practice. Methods: The search was conducted across multiple medical databases from inception to January 1, 2022 and performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A random effects model was used to calculate the overall effects. Results: Eighteen trials (1113 participants) were included. Antioxidant supplements significantly improved insulin resistance (95% CI, −0.62, −0.30; p < 0.00001; I² =48%), fasting insulin (95% CI, −0.80, −0.44; p < 0.00001; I² = 48%), and fasting plasma glucose (95% CI, −0.54, −0.21; p < 0.00001; I² = 38%) in patients with PCOS. However, antioxidant supplements were found to not improve most indices of lipid profiles in PCOS except triglyceride. Conclusions: Antioxidant supplements are an effective intervention for relieving insulin resistance but do not significantly improve lipid metabolism in women with PCOS.

摘要

目的

抗氧化剂补充剂对多囊卵巢综合征(PCOS)患者糖代谢和血脂的影响仍存在争议。这项系统综述和荟萃分析旨在评估抗氧化剂补充剂是否能改善PCOS患者的糖代谢和血脂状况, 以便在临床实践中提供最佳的营养补充建议。

方法

检索多个医学数据库从创建到2022年1月1日的文献, 并遵循系统综述及Meta分析首选项目报告条目(PRISMA)指南。采用随机效应模型计算总体效应。

结果

共纳入18项试验(1113名参与者)。抗氧化剂可显著改善PCOS患者的胰岛素抵抗(95%CI, −0.62, −0.30；p<0.00001；I2=48%)、空腹胰岛素(95%CI, −0.80, −0.44；p<0.00001；I2=48%)和空腹血糖(95%CI, −0.54, −0.21；p<0.00001；I2=38%)。然而, 抗氧化剂补充剂并不能改善PCOS患者除甘油三酯外的大多数血脂指标。

结论

抗氧化剂补充剂是缓解胰岛素抵抗的有效干预措施, 但不能显著改善PCOS患者的脂代谢。

Keywords:

• Antioxidant supplements
• polycystic ovary syndrome
• glucose metabolism
• lipid profiles
• meta-analysis
• oxidative stress

关键词:

• 抗氧化剂补充剂
• 多囊卵巢综合征
• 糖代谢
• 血脂谱
• 荟萃分析
• 氧化应激

Acknowledgements, avoiding identifying any of the authors prior to peer review 1. This is a note. The style name is Footnotes, but it can also be applied to endnotes.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

China Zhang Qin Famous Old Chinese Medicine Experts Inheritance Studio Construction Project(GZS202202).