A practical approach to the management of thyroid dysfunction during pregnancy

Abstract

Pregnancy has an important impact on the thyroid gland and its function. Thyroid activity changes as a consequence of the novel physiological state of pregnancy and requires a complex hormonal and metabolic adaptation, which is possible only in the presence of a perfectly functioning thyroid gland. In fact, thyroid function is crucial for the success of the implantation and the progression of pregnancy. Abnormal thyroid function is very common among childbearing age women, explaining the high incidence of thyroid diseases that occur during pregnancy. Aim of this work is to analyze the adaptive events that characterize the thyroid function during pregnancy, exploring their hormonal, metabolic and molecular mechanisms. Moreover, the interpretation of the laboratory data necessary to monitor the thyroid functioning during normal pregnancy or in the presence of thyroid abnormalities will be discussed.

摘要

妊娠对甲状腺及其功能有重要影响。甲状腺活动由于妊娠的新生理状态而发生变化, 需要复杂的激素和代谢适应, 这只有在甲状腺功能完全正常的情况下才可能发生。事实上, 甲状腺功能对于着床的成功和妊娠的进展至关重要。甲状腺功能异常在育龄期女性中很常见, 这解释了妊娠期甲状腺疾病高发的原因。本研究目的是分析代谢适应的特点, 探索妊娠期甲状腺激素代谢和分子机制。此外, 还将讨论在妊娠期正常或存在甲状腺异常时监测甲状腺功能所需实验室检测值的解释。

Keywords:

• Thyroid diseases
• thyrotropin
• pregnancy
• levothyroxine
• thyroid screening tests
• pregnancy complications

关键词:

• 甲状腺疾病
• 促甲状腺素
• 妊娠
• 左旋甲状腺素
• 甲状腺检查
• 妊娠并发症

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

The author(s) reported there is no funding associated with the work featured in this article.