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Abstract
Objective
To examine the effect of letrozole on oocyte quality and pregnancy outcome in assisted reproductive technology (ART).
Methods
This double blind placebo controlled clinical trial was conducted in Vali-Asr Infertility Center. Infertile women candidate for IVF that underwent antagonist protocol were selected. Eligible women randomly allocated into treatment (letrozole/Let group) and control (placebo) group. Participants received letrozole 5 mg/day or placebo at the time of gonadotropin start until trigger day in the same manner. Number of oocyte retrieved, metaphase II oocyte number, high grade oocyte number (G1), high quality embryo, Chemical and clinical pregnancy rate and OHSS (ovarian hyperstimulation syndrome) rate was recorded. 216 infertile women (104 in letrozole and 112 in the control group) were evaluated.
Results
In the Let group estradiol level was significantly lower (p_value < .001) and testosterone significantly higher than in the control group (p_value = .02). The number of retrieved oocytes, MII oocytes, G1 oocytes, and 2PN was significantly lower in the Let group (p < .05). No significant difference was found in the day of stimulation, total gonadotropin dose, OHSS rate, and clinical pregnancy rate between the two groups (p > 0.05).
Conclusions
According to the results, letrozole may reduce oocyte quality and cause poor IVF outcomes as well.
摘要
目的
探讨来曲唑对辅助生殖技术(ART)中卵母细胞质量和妊娠结局的影响。
方法
在Vali-Asr不孕中心进行双盲安慰剂对照临床试验。选择接受拮抗治疗的不孕妇女进行体外受精。符合条件的妇女随机分为治疗组(来曲唑/Let组)和对照组(安慰剂组)。在促性腺激素开始时, 参与者以同样的方式接受来曲唑5 mg/天或安慰剂。记录检索到的卵母细胞数、中期II卵母细胞数、高级别卵母细胞数(G1)、优质胚胎数、化学和临床妊娠率、卵巢过度刺激综合征(OHSS)发生率。对216例不孕妇女(来曲唑组104例, 对照组112例)进行评价。
结果
Let组雌二醇水平明显低于对照组(p_value < .001), 睾酮水平明显高于对照组(p_value = .02)。Let组获得的卵母细胞、MII卵母细胞、G1卵母细胞、2PN数量显著降低(p < 0.05)。两组在刺激天数、促性腺激素总剂量、OHSS率、临床妊娠率等方面差异无统计学意义(p > .05)。
结论
来曲唑可降低卵母细胞质量, 导致体外受精不良。
Data availability statement
Data is available on request.
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
The author(s) reported there is no funding associated with the work featured in this article.