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Abstract
Objectives
This study aims to determine serum levels of human Krüppel-like factors (KLFs), sP-selectin and sE-selectin and establish correlations between them in patients with gestational diabetes mellitus (GDM).
Methods
Twenty-six GDM patients aged between 22 and 35 years and 25 healthy pregnant women aged between 23 and 34 years were recruited. Maternal serum levels of KLF2, KLF4, and their target proteins sP-selectin, sE-selectin were measured using enzyme-linked immunosorbent assays at 24–28 weeks of gestation.
Results
Women with GDM had significantly lower serum KLF2 than controls. However, the differences in levels of serum KLF4 between the control and GDM groups were not significant. Additionally, elevated serum sP-selectin and sE-selectin were found in the GDM group and not in the healthy group. Importantly, we also found that serum KLF2 levels were negatively correlated with indicators of glucose metabolism, including insulin, fasting blood glucose, 1-h oral glucose tolerance test, and glycated hemoglobin.
Conclusion
We conclude that (i) serum KLF2 might be indicative of GDM risk, and (ii) sP-selectin and sE-selectin were increased in GDM patients.
摘要
目的
本研究旨在测定妊娠期糖尿病（gestational diabetes mellitus, GDM）患者血清中人Krüppel样因子（Krüppel-like factors, KLFs）、sP-选择素（sP-selectin）和sE-选择素（sE-selectin）的水平, 并建立它们之间的相关性。
方法
招募26名22-35岁之间的GDM患者和25名23-34岁之间的健康孕妇。在妊娠24-28周时, 使用酶联免疫吸附试验测定了母亲血清中KLF2、KLF4及其靶蛋白sP-选择素、sE-选择素的水平。
结果
GDM组的血清KLF2水平显著低于对照组。然而, 对照组和GDM组之间血清KLF4水平的差异并不显著。此外, 与对照组相比, GDM组血清sP-选择素和sE-选择素均升高。重要的是, 我们还发现血清KLF2水平与葡萄糖代谢指标（包括胰岛素、空腹血糖、1小时口服葡萄糖耐量试验和糖化血红蛋白）呈负相关。
结论
我们发现（1）血清KLF2可能提示GDM风险, （2）GDM患者血清sP-选择素和sE-选择素水平升高。
Disclosure statement
No potential conflict of interest was reported by the authors.