Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and endometriosis in a Japanese population

Abstract

Objective. We investigated a possible association between endometriosis and polymorphisms in the genes encoding epidermal growth factor (EGF) receptor (EGFR) and EGF in a Japanese population.

Methods. We compared the distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms by polymerase chain reaction–restriction fragment length polymorphism analysis in 146 affected women and 181 controls.

Results. No significant differences in the frequency and genotype distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms were found between endometriosis patients with all disease stages and controls. Stratification by disease stage had no effect on the results.

Conclusion. The Egfr+2073 A/T and Egf+61 G/A polymorphisms are not associated with an increased risk of endometriosis in a Japanese population.

Keywords:

• Endometriosis
• gene polymorphism
• polymerase chain reaction
• restriction fragment length polymorphism
• epidermal growth factor receptor
• epidermal growth factor