Clopidogrel inhibits shear-induced platelet function

James L. Orford Cardiac Catheterization Laboratory, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA

Scott Kinlay Cardiac Catheterization Laboratory, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA

Mark R. Adams Cardiac Catheterization Laboratory, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA

Daniel I. Simon Cardiac Catheterization Laboratory, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA

Andrew P. Selwyn Cardiac Catheterization Laboratory, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA

Abstract

We enrolled 17 healthy adult volunteers and measured platelet hemostasis time (PHT) and collagen-induced thrombus formation (CITF) before and after the oral administration of 300 mg of clopidogrel utilizing the Xylum Clot Signature Analyzer®. We documented a statistically significant 30% prolongation of the PHT from 291 - 13 (SE) seconds to 376 - 31 (SE) s ( P =0.037). There was a 7% prolongation of the CITF from 347 - 10 to 371 - 17 (SE) s ( P =0.245). This study suggests that the Xylum Clot Signature Analyzer can measure changes in platelet function in response to a modest platelet inhibitor, and may be a useful clinical tool for the monitoring of antiplatelet therapies in patients.

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Clopidogrel inhibits shear-induced platelet function

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Clopidogrel inhibits shear-induced platelet function

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