Fabric-staining properties and washability of a novel liposomal dithranol formulation

Abstract

AIM: To test the staining potential of a novel liposomal dithranol gel on different types of fabrics and compare it with the only commercially available dithranol preparation in India, DerobinA. METHODS: Pure cotton, pure polyester and four blends of the two fabrics were tested for staining and washability. RESULTS : Both products showed the least staining and spreading on pure cotton with progressively worse stains as the proportion of polyester in the fabric increased. When compared with each other the liposomal dithranol gel showed markedly lighter staining than Derobin on all fabrics. It also washed off completely with water whereas the Derobin stains could not be washed off, even with detergent. CONCLUSION: The liposomal gel due to its superior staining properties may potentially increase the acceptability of dithranol amongst psoriasis patients.

• Dithranol
• Liposome
• Psoriasis
• Topical
• Therapy