Abstract
Aim
This case study aims to report the efficacy and safety of a Janus kinase (JAK) inhibitor in the treatment of generalized eosinophilic pustular folliculitis (EPF).
Methods
We present a case of a 16-year-old Chinese patient who had been suffering from EPF for two years and had shown no response to both topical and systemic glucocorticoids. The patient was subsequently treated with oral tofacitinib at a dosage of 5mg daily.
Results
Significant remission of eruption and pruritus was observed in the patient upon treatment with tofacitinib. However, a relapse occurred upon dose reduction. Subsequent switch to the highly selective JAK1 inhibitor upadacitinib resulted in complete recovery, with the patient achieving a symptom-free status after six months.
Conclusions
JAK inhibitors show promise as a potential treatment option for EPF patients who do not respond to traditional therapies.
Ethics statement
The patient consent was obtained to publication of the case details in this manuscription.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
All data generated or used during the case appear in the submitted manuscription.