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International Journal of Radiation Biology Volume 77, 2001 - Issue 6
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Research Article

Level of Flt3-ligand in plasma: a possible new bio-indicator for radiation-induced aplasia

J.-M. Bertho Institut de Protection et de Sûreté Nucléaire, Département de Protection de la Santé de L'homme et de Dosimétrie, Section Autonome de Radiobiologie Appliquée à la Médecine and Laboratoire de Thérapie Cellulaire et de Radioprotection Accidentelle, CHU Saint-Antoine, Paris, France.
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C. Demarquay Institut de Protection et de Sûreté Nucléaire, Département de Protection de la Santé de L'homme et de Dosimétrie, Section Autonome de Radiobiologie Appliquée à la Médecine and Laboratoire de Thérapie Cellulaire et de Radioprotection Accidentelle, CHU Saint-Antoine, Paris, France.
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J. Frick Institut de Protection et de Sûreté Nucléaire, Département de Protection de la Santé de L'homme et de Dosimétrie, Section Autonome de Radiobiologie Appliquée à la Médecine.
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C. Joubert Institut de Protection et de Sûreté Nucléaire, Département de Protection de la Santé de L'homme et de Dosimétrie, Section Autonome de Radiobiologie Appliquée à la Médecine.
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S. Arenales Institut de Protection et de Sûreté Nucléaire, Département de Protection de la Santé de L'homme et de Dosimétrie, Section Autonome de Radiobiologie Appliquée à la Médecine and Laboratoire de Thérapie Cellulaire et de Radioprotection Accidentelle, CHU Saint-Antoine, Paris, France.
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N. Jacquet Laboratoire de Dosimétrie Biologique Multiparamétrique rue Auguste Lemaire, BP6, F-92265 Fontenay-aux-Roses Cedex, France.
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I. Sorokine-Durm Service de Dosimétrie, rue Auguste Lemaire, BP6, F-92265 Fontenay-aux-Roses Cedex, France.
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Quang Chau Institut de Protection et de Sûreté Nucléaire, Département de Protection de la Santé de L'homme et de Dosimétrie, Section Autonome de Radiobiologie Appliquée à la Médecine and Laboratoire de Thérapie Cellulaire et de Radioprotection Accidentelle, CHU Saint-Antoine, Paris, France.
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M. Lopez Laboratoire de Thérapie Cellulaire et de Radioprotection Accidentelle, CHU Saint-Antoine, Paris, France and INSERM U76, CHU Saint-Antoine, Paris, France.
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J. Aigueperse Institut de Protection et de Sûreté Nucléaire, Département de Protection de la Santé de L'homme et de Dosimétrie, Section Autonome de Radiobiologie Appliquée à la Médecine and Laboratoire de Thérapie Cellulaire et de Radioprotection Accidentelle, CHU Saint-Antoine, Paris, France.
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N.-C. Gorin Laboratoire de Thérapie Cellulaire et de Radioprotection Accidentelle, CHU Saint-Antoine, Paris, France and Service des maladies du sang, Hôpital Saint-Antoine, Paris, France.
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P. Gourmelon Institut de Protection et de Sûreté Nucléaire, Département de Protection de la Santé de L'homme et de Dosimétrie, Section Autonome de Radiobiologie Appliquée à la Médecine and Laboratoire de Thérapie Cellulaire et de Radioprotection Accidentelle, CHU Saint-Antoine, Paris, France.
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Pages 703-712 | Published online: 03 Jul 2009
 
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Abstract

Purpose : To follow plasma Flt3-ligand (FL) concentrations in irradiated animals in order to evaluate it as an indicator of bone marrow damage for the management of accidental radiation-induced aplasia. Materials and methods : Non-human primates were irradiated at doses ranging from 2 to 8 Gy, using whole- or partial-body irradiation. Plasma FL concentrations and blood cell counts were determined daily. Results : FL concentrations increased as early as day 2 after irradiation, whatever the irradiation dose. Increase in plasma FL concentration on day 5 post-irradiation was correlated with radiation dose and with the severity of radiation-induced aplasia. During the course of aplasia, FL concentrations in plasma were inversely correlated with neutrophil counts. A peak in FL concentration appeared before the neutrophil nadir, and the subsequent decrease in FL concentration was correlated with the recovery of blood-cell populations. Conclusions : Monitoring plasma FL concentration can be used as an indicator of radiation-induced marrow aplasia, and this may be of use in accidental irradiation situations.

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