Abstract
Purpose: Caveolae are non-clathrin, flask-shaped invaginations of the plasma membrane. Caveolin-1 is an essential constituent of caveolae and as such acts as a regulator of caveolae-dependent lipid trafficking and endocytosis. Caveolin-1 interacts with a variety of cellular proteins and regulates cell-signaling events.
Caveolin-1 appears to act as a tumor suppressor protein at early stages of cancer progression. However, a growing body of evidence indicates that caveolin-1 is up-regulated in several multidrug-resistant and metastatic cancer cell lines and human tumor specimens. Furthermore, caveolin-1 levels are positively correlated with tumor stage and grade in numerous cancer types.
Conclusion: The available experimental data support the tumor-promoting role of caveolin-1 in advanced-stage cancer.
Abbreviations | ||
ABCB1 | = | ATP-binding cassette, sub-family B, member 1; |
CAV1 | = | caveolin-1; |
Crk-I | = | CT10-regulated kinase-I; |
EGF | = | epidermal growth factor; |
eNOS | = | endothelial nitric oxide synthase; |
Erk1/2 | = | extracellular signal-regulated kinase 1/2; |
EWS | = | Ewing's sarcomas; |
FRT | = | Fisher rat thyroid cells; |
GlcCer | = | glucosylceramide; |
HUVEC | = | human umbilical vein endothelial cells; |
IGF-I | = | insulin-like growth factor I; |
MAPK | = | mitogen-activated protein kinase; |
MDR | = | multidrug resistance; |
MMP | = | matrix metallopeptidase; |
MRP1 | = | multidrug resistance-associated protein-1; |
NSCLC | = | non-small cell lung carcinoma; |
P-gp | = | P-glycoprotein; |
PI3K | = | Phosphoinositide 3-kinase; |
PNI | = | perineural invasion; |
Shc | = | Src homology domain containing; |
siRNA | = | short interfering RNA; |
TRAMP | = | transgenic adenocarcinoma of mouse prostate; |
PyMT | = | Polyoma virus middle T |
Abbreviations | ||
ABCB1 | = | ATP-binding cassette, sub-family B, member 1; |
CAV1 | = | caveolin-1; |
Crk-I | = | CT10-regulated kinase-I; |
EGF | = | epidermal growth factor; |
eNOS | = | endothelial nitric oxide synthase; |
Erk1/2 | = | extracellular signal-regulated kinase 1/2; |
EWS | = | Ewing's sarcomas; |
FRT | = | Fisher rat thyroid cells; |
GlcCer | = | glucosylceramide; |
HUVEC | = | human umbilical vein endothelial cells; |
IGF-I | = | insulin-like growth factor I; |
MAPK | = | mitogen-activated protein kinase; |
MDR | = | multidrug resistance; |
MMP | = | matrix metallopeptidase; |
MRP1 | = | multidrug resistance-associated protein-1; |
NSCLC | = | non-small cell lung carcinoma; |
P-gp | = | P-glycoprotein; |
PI3K | = | Phosphoinositide 3-kinase; |
PNI | = | perineural invasion; |
Shc | = | Src homology domain containing; |
siRNA | = | short interfering RNA; |
TRAMP | = | transgenic adenocarcinoma of mouse prostate; |
PyMT | = | Polyoma virus middle T |
Abbreviations | ||
ABCB1: | = | ATP-binding cassette, sub-family B, member 1; |
CAV1: | = | caveolin-1; |
Crk-I: | = | CT10-regulated kinase-I; |
EGF: | = | epidermal growth factor; |
eNOS: | = | endothelial nitric oxide synthase; |
Erk1/2: | = | extracellular signal-regulated kinase 1/2; |
EWS: | = | Ewing's sarcomas; |
FRT: | = | Fisher rat thyroid cells; |
GlcCer: | = | glucosylceramide; |
HUVEC: | = | human umbilical vein endothelial cells; |
IGF-I: | = | insulin-like growth factor I; |
MAPK: | = | mitogen-activated protein kinase; |
MDR: | = | multidrug resistance; |
MMP: | = | matrix metallopeptidase; |
MRP1: | = | multidrug resistance-associated protein-1; |
NSCLC: | = | non-small cell lung carcinoma; |
P-gp: | = | P-glycoprotein; |
PI3K: | = | Phosphoinositide 3-kinase; |
PNI: | = | perineural invasion; |
Shc: | = | Src homology domain containing; |
siRNA: | = | short interfering RNA; |
TRAMP: | = | transgenic adenocarcinoma of mouse prostate; |
PyMT: | = | Polyoma virus middle T |
Notes
This paper was presented at the Workshop on Radiation and Multidrug Resistance Mediated by the Tumor-Microenvironment, guest edited by Dr. Cordes and Dr. Mary Helen Barcellos-Hoff.