Abstract
Purpose
The aim of this article is to describe the technical development in proteomics during the last two decades with the focus on its use in radiation biology. It is written from a subjective point of view and aims not to be a scientific review of the subject.
Conclusion
Proteomics is a fast developing technique and it has already contributed greatly to our understanding of biological mechanisms following radiation exposure. Novel proteomics approaches can be used in adequately designed cellular and animal experiments and above all in big clinical trials to investigate effects of ionizing radiation in the future.
Acknowledgments
I would like to thank Mike Atkinson, Omid Azimzadeh, Zarko Barjaktarovic, Franka Pluder, Dominik Schmaltz, Alena Shyla, Arundhathi Sriharshan, Prabal Subedi, Ramesh Yentrapalli, Stefan J. Kempf, Mayur Bakshi, Vikram Subramanian, Daniela Hladik, Jos Philipp, and Helmholtz Proteomics Core Facility for making this paper possible.
Disclosure statement
The author reports no conflict of interest.
Additional information
Funding
Notes on contributors
Soile Tapio
Soile Tapio (PhD) is an Adjunct Professor (Docent) of Radiation Biology at Technical University Munich, Munich, Germany. She leads the group of Radiation Proteomics at the Institutes of Radiation Biology and Institute for Biological and Medical Imaging at Helmholtz Center Munich, Germany. Her research topic is radiation-induced normal tissue damage in heart and brain.