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Summary
The replacement of bone marrow in rabbits subjected to high dose-levels of irradiation has been investigated. Since doses large enough to destroy the marrow of rabbits cause fatal damage to other organs, colloidal 198Au was used as a source of selective irradiation of bone marrow and other haematopoietic tissues, followed by marrow transfusions.
It has been found that 198Au will produce severe hypoplasia, or even complete aplasia, without causing acute radiation damage to other organs. Roughly half the 198Au is taken up by the marrow and almost all the rest by the liver. Results from two series of rabbits from which the spleen was removed do not suggest that splenectomy has any significant effect on survival.
At certain dose-levels, the survival-rate is substantially increased by marrow transfusions. Increased survival-rate and recovery of leucocyte-count was found only after double transfusions. Both controls and transfused animals which survived for more than 14 days after LD 65 continued to survive indefinitely.