Evaluation of Radio-protective Efficacy of Cysteamine (with Rat-liver-cell Glycogen as Reference System)

Summary

A technique for localization of glycogen in the hepatic-cell cytoplasm of rats was utilized for determination of the radio-protective efficacy of cysteamine with 15 mg dose per animal.

Radiation-induced glycogenesis was at its maximum peak 24 hours after irradiation with 300 r, 500 r and 800 r.

After irradiation with 500 r, protective efficacy was maximal at 4 days and 13 days after irradiation. After 300 r and 800 r, efficacy was maximal at 4 days and 3 days after irradiation, respectively.