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Summary
The mode of action of NO as a modifier of radiation sensitivity in aqueous suspensions of Shigella flexneri is different from that of O2.
(1) NO present during irradiation has a sensitizing effect which is similar, but not chemically equivalent, to that due to O2.
(2) Exposure to NO followed by removal of the gas prior to irradiation (i.e. pre-treatment) causes a latent irreversible effect on the bacteria, which becomes manifest after irradiation as enhanced radiation sensitivity dependent on concentration of NO and on the time of contact.
(3) NO has also a relative protective effect.
A tentative hypothesis based on the fixation of NO by unknown cell constituents is suggested.