Protective Effectiveness of Cystamine Versus Delay of Exposure, Body Temperature and Protein Linkage

Summary

In rats which received an intraperitoneal injection of cystamine, the protective effectiveness against whole-body irradiation reached a maximum 10 min after administration. No correlation existed between the total amount of cystamine detected in different tissues at various time-intervals after injection and the degree of protection afforded. Neither was there any parallelism between the time variations of protective effectiveness and the amount of free or protein-bound cystamine in the tissues.