Studies on the Metabolism of Tissue Proteins

II. Influence of X-irradiation and Starvation on the Metabolism of Collagen

G.B. Gerber Division of Experimental Radiology, University of Rochester School of Medicine and Dentistry, 260 Crittenden Blvd., 20, Rochester, New York

G. Gerber Division of Experimental Radiology, University of Rochester School of Medicine and Dentistry, 260 Crittenden Blvd., 20, Rochester, New York

K.I. Altman Division of Experimental Radiology, University of Rochester School of Medicine and Dentistry, 260 Crittenden Blvd., 20, Rochester, New York

L.H. Hempelmann Division of Experimental Radiology, University of Rochester School of Medicine and Dentistry, 260 Crittenden Blvd., 20, Rochester, New York

Summary

Rats were injected with proline-U-¹⁴C and exposed to total-body x-irradiation at various time-intervals thereafter. Proline and hydroxyproline were isolated from collagen of various organs as well as from sub-fractions of skin collagen and their specific activity determined. From the changes in specific activity of proline and hydroxyproline observed after exposure it is postulated that more metabolically-active collagen is degraded and that the conversion of soluble to insoluble collagen is partially inhibited after irradiation.

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Studies on the Metabolism of Tissue Proteins

II. Influence of X-irradiation and Starvation on the Metabolism of Collagen

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Studies on the Metabolism of Tissue Proteins

II. Influence of X-irradiation and Starvation on the Metabolism of Collagen

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