Studies on the Metabolism of Tissue Proteins

III. The Turnover of Soluble Proteins and Elastin Labelled with ¹⁴C proline and its Relation to Exposure to Total-body X-irradiation

G.B. Gerber Division of Experimental Radiology, University of Rochester School of Medicine and Dentistry, Rochester, New York

G. Gerber Division of Experimental Radiology, University of Rochester School of Medicine and Dentistry, Rochester, New York

K.I. Altman Division of Experimental Radiology, University of Rochester School of Medicine and Dentistry, Rochester, New York

L.H. Hempelmann Division of Experimental Radiology, University of Rochester School of Medicine and Dentistry, Rochester, New York

Summary

Rats were injected with proline-U-¹⁴C and exposed to total-body x-irradiation at various time-intervals thereafter. Proline was isolated from the soluble protein and elastin fractions of various organs and its specific activity determined. In most organs an increase in specific activity of proline of these two protein fractions was observed after irradiation. This was interpreted to mean either a lowered metabolic replacement or a loss of certain components from these protein fractions after irradiation. It is suggested that the decrease in specific activity observed in the spleen is correlated to changes in the cell-population in this organ after irradiation.

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Studies on the Metabolism of Tissue Proteins

III. The Turnover of Soluble Proteins and Elastin Labelled with ¹⁴C proline and its Relation to Exposure to Total-body X-irradiation

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Studies on the Metabolism of Tissue Proteins

III. The Turnover of Soluble Proteins and Elastin Labelled with 14C proline and its Relation to Exposure to Total-body X-irradiation

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III. The Turnover of Soluble Proteins and Elastin Labelled with ¹⁴C proline and its Relation to Exposure to Total-body X-irradiation