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Summary
Methysergide (1-methyl-D-lysergic acid butanolamide bimaleate), a highly potent and specific 5-hydroxytryptamine antagonist, if injected after irradiation, significantly depresses the prolonging effect of x-irradiation on the barbiturate sleeping-time in rats. Lysergic acid diethylamide did not show this type of activity.
5-Hydroxytryptamine, when injected before irradiation, did not depress the typical response of the irradiated animals to barbiturates. When used after irradiation, 5-hydroxytryptamine caused a further prolongation of the barbiturate sleeping-time.
Cysteamine, when injected before irradiation, depressed or blocked the prolonging effect of x-irradiation on the barbiturate sleeping-time. When injected after irradiation, cysteamine was found to cause a further prolongation of the barbiturate sleeping-time. The mechanisms of action of methysergide, 5-hydroxytryptamine and cysteamine are briefly discussed.