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Summary
The effect of x-irradiation at various oxygen-concentrations has been examined in a strain of Pseudomonas aeruginosa.
The relationship between the logarithm of the oxygen-concentration and the fraction of the bacterial population surviving a given fixed value of the radiation dose can be adequately described by a simple transformation of the equation of a cumulative normal curve. This has already been demonstrated in the case that the dose–survival curve is linear on a logarithmic plot (van Soestbergen 1962). The present investigation confirms this observation with data derived from an experiment where the dose–survival curve is of a non-linear type.
It is shown that the oxygen-concentration at which a response of specified magnitude is obtained decreases exponentially with the radiation dose. The radiosensitivity of the bacterial population, defined as a function of the oxygen-concentration at which an effect of specified magnitude is obtained, increases exponentially with the radiation dose.