The Interaction of Yttrium with Constituents of Bone and Other Compounds

Summary

The binding properties of yttrium with a variety of organic compounds have been investigated using an ion-exchange resin. EDTA had the greatest affinity, then citrate, isocitrate and malate, the binding being less at lower ph values. Serum albumin showed some binding, which decreased after hydrolysis with 6 N HC1 at 100°c. EDTA and citrate had far weaker chelating properties with ⁸⁹Sr than ⁹¹Y. Extracts prepared from cortical beef-bone powder were found to possess only weak binding with yttrium, which decreased on dialysing the extract. If untreated bone powder was used in place of resin, the uptake of ⁹¹Y and ⁸⁹Sr was less at the lower ph values. If the bone powder was ashed, ⁸⁹Sr-uptake was unaffected, but ⁹¹Y-uptake was high at all ph values. It is suggested that citrate may be a factor determining the uptake of yttrium in bone.