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Summary
The genetic effects of radiation on mice were studied by applying chronic gamma-irradiation from conception to reproduction for three successive generations. The frequency of autosomal recessive lethals estimated by Haldane's method, litter-size, rate of early death, and sex-ratio were compared for the offspring of irradiated and non-irradiated ancestors.
The dose-rate used was as low as 0·43 r/22 hr.-day, and the accumulated dose for each generation was about 34·4 r.
A significant difference was observed in some of the above points.
The rates of mutation to various kinds of recessive lethals were calculated.
The genetic effect of radiation on mice was demonstrated at a low dose with a low dose-rate. The results may be very significant for the assessment of human radiation hazards.