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Summary
The content of radiopotassium 42K in various organs and in the blood and serum was studied in rats, both after total-body irradiation with 1000 r x-rays and after the administration of a single dose of L-methionine sulphoximine (150 mg/kg body-weight), and compared with that in controls given radiopotassium alone.
The results of the investigations were:
1. Both after irradiation and after the administration of L-methionine sulphoximine, a diminution of the radiopotassium content in the thymus and in the pancreas was noted, compared with controls.
2. The administration of L-methionine sulphoximine was followed by an increase of the 42K content in the adrenals, which was not observed after exposure to x-radiation.
3. Both x-rays and the administration of L-methionine sulphoximine were followed by a marked increase of the radiopotassium content in the kidneys.
The changes of the radiopotassium content in various organs of the rat observed in our studies after x-radiation and after a single dose of L-methionine sulphoximine were, to a certain degree, analogous.